522.540 Dexamethasone injection.

Specifications: The drug is a sterile aqueous solution. Each milliliter contains 4.0 milligrams of dexamethasone sodium phosphate (equivalent to 3.0 milligrams of dexamethasone).

Conditions of use:

Dogs

Amount: 0.25 to 1 milligram initially, administered intravenously. May be repeated for 3 to 5 days or until response is noted.

Indications: The drug is given for glucocorticoid and anti-inflammatory agent.

Limitations: If permanent glucocorticoid effect is required, oral therapy may be substituted. When therapy is to be withdraw after prolonged use, the daily dose should be reduced gradually over several days. Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Do not use in viral infections. Anti-inflammatory action of glucocorticoids may mask signs of infection. Except when used for emergency therapy, the product is contraindicated in animals with tuberculosis, chronic nephritis, cushingoid syndrome, or peptic ulcers. .Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Horses

Amount: 2.5 to 5 milligrams administered intravenously.

Indications: The drug is given for glucocorticoid and anti-inflammatory agent.

Limitations: If permanent glucocorticoid effect is required, oral therapy may be substituted. When therapy is to be withdraw after prolonged use, the daily dose should be reduced gradually over several days. Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis. Do not use in viral infections. Anti-inflammatory action of glucocorticoids may mask signs of infection. Except when used for emergency therapy, the product is contraindicated in animals with tuberculosis, chronic nephritis, cushingoid syndrome, or peptic ulcers. Not for use in horses intended for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.