Dihydrostreptomycin

522.650 Dihydrostreptomycin sulfate injection.

Specifications: Each milliliter contains dihydrostreptomycin sulfate equivalent to 500 milligrams of dihydrostreptomycin.

Conditions of use:

Dogs

Amount: 5 milligrams per pound of body weight every 12 hours. Administer by deep intramuscular injection.

Indications: Treatment of leptospirosis in dogs due to Leptospira canicola, L. Icterohemorrhagiae, and L. pomona.

Limitations: Treatment should be continued for 3 to 5 days or until the urine is free of leptospira for at least 72 hours as measured by darkfield microscopic examination. Treatment with subtherapeutic dosages, excessive duration of therapy, or inappropriate use of this antibiotic may lead to the emergence of streptomycin or dihydrostreptomycin resistant organisms. Discontinued use 30 days slaughter for food. Not for use in animals producing milk because use of this drug will result in contamination of the milk. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Horses

Amount: 5 milligrams per pound of body weight every 12 hours Administer by deep intramuscular injection.

Indications: Treatment of leptospirosis in horses due to Leptospira canicola, L. icterohemorrhagiae, and L. pomona.

Limitations: Treatment should be continued for 3 to 5 days or until the urine is free of leptospira for at least 72 hours as measured by darkfield microscopic examination. Treatment with subtherapeutic dosages, excessive duration of therapy, or inappropriate use of this antibiotic may lead to the emergence of streptomycin or dihydrostreptomycin resistant organisms. Discontinued use 30 days slaughter for food. Not for use in animals producing milk because use of this drug will result in contamination of the milk. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Cattle

Amount: 5 milligrams per pound of body weight every 12 hours. Administer by deep intramuscular injection.

Indications: Treatment of leptospirosis in cattle due to L. pomona.

Limitations: Treatment should be continued for 3 to 5 days or until the urine is free of leptospira for at least 72 hours as measured by darkfield microscopic examination. Treatment with subtherapeutic dosages, excessive duration of therapy, or inappropriate use of this antibiotic may lead to the emergence of streptomycin or dihydrostreptomycin resistant organisms. Discontinued use 30 days slaughter for food. Not for use in animals producing milk because use of this drug will result in contamination of the milk. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Swine

Amount: 5 milligrams per pound of body weight every 12 hours Administer by deep intramuscular injection.

Indications: Treatment of leptospirosis in swine due to L. pomona and L. grippotyphosa.

Limitations: Treatment should be continued for 3 to 5 days or until the urine is free of leptospira for at least 72 hours as measured by darkfield microscopic examination. Treatment with subtherapeutic dosages, excessive duration of therapy, or inappropriate use of this antibiotic may lead to the emergence of streptomycin or dihydrostreptomycin resistant organisms. Discontinued use 30 days slaughter for food. Federal law restricts this drug to use by or on the order of a licensed veterinarian.

NAS/NRC status: These conditions are NAS/NRC reviewed and found effective. Applications for these uses need not include effectiveness data as specified by 514.111 of this chapter but may require bioequivalency and safety information.

Tolerances are established for residues of dihydrostreptomycin in uncooked, edible tissues of cattle and swine of 2.0 parts per million (ppm) in kidney and 0.5 ppm in other tissues, and 0.125 part per million in milk.